Running: ./testmodel.py --libraries=/home/hudson/saved_omc/libraries/.openmodelica/libraries --ompython_omhome=/usr Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.conf.json loadFile("/home/hudson/saved_omc/libraries/.openmodelica/libraries/ModelicaServices 4.1.0+maint.om/package.mo", uses=false) [Timeout 180] "Notification: Performance of loadFile(/home/hudson/saved_omc/libraries/.openmodelica/libraries/ModelicaServices 4.1.0+maint.om/package.mo): time 0.001413/0.001413, allocations: 100.3 kB / 19.71 MB, free: 440 kB / 13.93 MB " [Timeout remaining time 180] loadFile("/home/hudson/saved_omc/libraries/.openmodelica/libraries/Complex 4.1.0+maint.om/package.mo", uses=false) [Timeout 180] "Notification: Performance of loadFile(/home/hudson/saved_omc/libraries/.openmodelica/libraries/Complex 4.1.0+maint.om/package.mo): time 0.001526/0.001526, allocations: 212.9 kB / 23 MB, free: 2.984 MB / 13.93 MB " [Timeout remaining time 180] loadFile("/home/hudson/saved_omc/libraries/.openmodelica/libraries/Modelica 4.1.0+maint.om/package.mo", uses=false) [Timeout 180] "Notification: Performance of loadFile(/home/hudson/saved_omc/libraries/.openmodelica/libraries/Modelica 4.1.0+maint.om/package.mo): time 1.014/1.014, allocations: 230.6 MB / 256.8 MB, free: 9.602 MB / 202.7 MB " [Timeout remaining time 179] loadFile("/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/package.mo", uses=false) [Timeout 180] "[/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Examples/package.order:0:0-0:0:readonly] Warning: The package.order file does not list all .mo files and directories (containing package.mo) present in its directory. Missing names are: Paracetamol_Experiment Notification: Performance of loadFile(/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/package.mo): time 1.662/1.662, allocations: 334.2 MB / 0.6323 GB, free: 7.93 MB / 442.7 MB " [Timeout remaining time 178] Using package Pharmacolibrary with version 25.09 (/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/package.mo) Using package Modelica with version 4.1.0 (/home/hudson/saved_omc/libraries/.openmodelica/libraries/Modelica 4.1.0+maint.om/package.mo) Using package Complex with version 4.1.0 (/home/hudson/saved_omc/libraries/.openmodelica/libraries/Complex 4.1.0+maint.om/package.mo) Using package ModelicaServices with version 4.1.0 (/home/hudson/saved_omc/libraries/.openmodelica/libraries/ModelicaServices 4.1.0+maint.om/package.mo) Running command: translateModel(Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic,tolerance=1e-12,outputFormat="empty",numberOfIntervals=864,variableFilter="",fileNamePrefix="Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic") translateModel(Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic,tolerance=1e-12,outputFormat="empty",numberOfIntervals=864,variableFilter="",fileNamePrefix="Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic") [Timeout 660] "Notification: Pharmacolibrary requested package Modelica of version 4.0.0. Modelica 4.1.0 is used instead which states that it is fully compatible without conversion script needed. Notification: Performance of FrontEnd - loaded program: time 0.001725/0.001725, allocations: 75.88 kB / 0.867 GB, free: 8.121 MB / 0.573 GB Notification: Performance of FrontEnd - Absyn->SCode: time 0.1691/0.1708, allocations: 112.8 MB / 0.9772 GB, free: 7.043 MB / 0.6824 GB Notification: Performance of NFInst.instantiate(Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic): time 0.008071/0.1789, allocations: 11.67 MB / 0.9886 GB, free: 11.32 MB / 0.698 GB Notification: Performance of NFInst.instExpressions: time 0.3827/0.5616, allocations: 2.654 MB / 0.9912 GB, free: 18.76 MB / 0.698 GB Notification: Performance of NFInst.updateImplicitVariability: time 0.0005298/0.5622, allocations: 23.19 kB / 0.9912 GB, free: 18.75 MB / 0.698 GB Notification: Performance of NFTyping.typeComponents: time 0.0004402/0.5626, allocations: 311 kB / 0.9915 GB, free: 18.75 MB / 0.698 GB Notification: Performance of NFTyping.typeBindings: time 0.001039/0.5636, allocations: 0.8593 MB / 0.9923 GB, free: 18.37 MB / 0.698 GB Notification: Performance of NFTyping.typeClassSections: time 0.0006993/0.5643, allocations: 0.6698 MB / 0.993 GB, free: 18.36 MB / 0.698 GB Notification: Performance of NFFlatten.flatten: time 0.001524/0.5659, allocations: 3.143 MB / 0.9961 GB, free: 17.61 MB / 0.698 GB Notification: Performance of NFFlatten.resolveConnections: time 0.0004571/0.5663, allocations: 452.6 kB / 0.9965 GB, free: 17.52 MB / 0.698 GB Notification: Performance of NFEvalConstants.evaluate: time 0.0007166/0.567, allocations: 1.083 MB / 0.9976 GB, free: 17.33 MB / 0.698 GB Notification: Performance of NFSimplifyModel.simplify: time 0.001039/0.5681, allocations: 1.063 MB / 0.9986 GB, free: 16.87 MB / 0.698 GB Notification: Performance of NFPackage.collectConstants: time 0.0003197/0.5684, allocations: 282.5 kB / 0.9989 GB, free: 16.87 MB / 0.698 GB Notification: Performance of NFFlatten.collectFunctions: time 0.0003921/0.5688, allocations: 285.3 kB / 0.9991 GB, free: 16.87 MB / 0.698 GB Notification: Performance of NFScalarize.scalarize: time 0.0002865/0.5691, allocations: 0.4936 MB / 0.9996 GB, free: 16.51 MB / 0.698 GB Notification: Performance of NFVerifyModel.verify: time 0.0008456/0.5699, allocations: 1.105 MB / 1.001 GB, free: 15.94 MB / 0.698 GB Notification: Performance of NFConvertDAE.convert: time 0.002093/0.572, allocations: 3.018 MB / 1.004 GB, free: 14.7 MB / 0.698 GB Notification: Performance of FrontEnd - DAE generated: time 3.296e-06/0.572, allocations: 0 / 1.004 GB, free: 14.7 MB / 0.698 GB Notification: Performance of FrontEnd: time 1.854e-06/0.572, allocations: 1.344 kB / 1.004 GB, free: 14.7 MB / 0.698 GB Notification: Performance of Transformations before backend: time 2.746e-05/0.572, allocations: 0 / 1.004 GB, free: 14.7 MB / 0.698 GB Notification: Model statistics after passing the front-end and creating the data structures used by the back-end: * Number of equations: 402 * Number of variables: 402 Notification: Performance of Generate backend data structure: time 0.00329/0.5753, allocations: 3.173 MB / 1.007 GB, free: 12.41 MB / 0.698 GB Notification: Performance of prepare preOptimizeDAE: time 3.946e-05/0.5754, allocations: 11.48 kB / 1.007 GB, free: 12.41 MB / 0.698 GB Notification: Performance of preOpt normalInlineFunction (simulation): time 0.0002894/0.5757, allocations: 255.2 kB / 1.007 GB, free: 12.27 MB / 0.698 GB Notification: Performance of preOpt evaluateParameters (simulation): time 0.001126/0.5768, allocations: 0.9768 MB / 1.008 GB, free: 11.62 MB / 0.698 GB Notification: Performance of preOpt simplifyIfEquations (simulation): time 8.714e-05/0.5769, allocations: 125 kB / 1.008 GB, free: 11.57 MB / 0.698 GB Notification: Performance of preOpt expandDerOperator (simulation): time 0.000239/0.5771, allocations: 195 kB / 1.008 GB, free: 11.5 MB / 0.698 GB Notification: Performance of preOpt clockPartitioning (simulation): time 0.002725/0.5798, allocations: 2.256 MB / 1.01 GB, free: 10.15 MB / 0.698 GB Notification: Performance of preOpt findStateOrder (simulation): time 6.524e-05/0.5799, allocations: 28.27 kB / 1.01 GB, free: 10.14 MB / 0.698 GB Notification: Performance of preOpt replaceEdgeChange (simulation): time 0.0001105/0.58, allocations: 65.7 kB / 1.011 GB, free: 10.09 MB / 0.698 GB Notification: Performance of preOpt inlineArrayEqn (simulation): time 3.077e-05/0.58, allocations: 37.66 kB / 1.011 GB, free: 10.09 MB / 0.698 GB Notification: Performance of preOpt removeEqualRHS (simulation): time 0.002413/0.5825, allocations: 2.022 MB / 1.013 GB, free: 9.043 MB / 0.698 GB Notification: Performance of preOpt removeSimpleEquations (simulation): time 0.00584/0.5883, allocations: 4.96 MB / 1.017 GB, free: 5.93 MB / 0.698 GB Notification: Performance of preOpt comSubExp (simulation): time 0.002562/0.5909, allocations: 1.99 MB / 1.019 GB, free: 4.727 MB / 0.698 GB Notification: Performance of preOpt resolveLoops (simulation): time 0.001328/0.5922, allocations: 1.259 MB / 1.021 GB, free: 3.812 MB / 0.698 GB Notification: Performance of preOpt evalFunc (simulation): time 7.929e-05/0.5923, allocations: 29.14 kB / 1.021 GB, free: 3.809 MB / 0.698 GB Notification: Performance of preOpt encapsulateWhenConditions (simulation): time 0.002584/0.5949, allocations: 2.973 MB / 1.024 GB, free: 1.52 MB / 0.698 GB Notification: Performance of pre-optimization done (n=264): time 3.516e-06/0.5949, allocations: 0 / 1.024 GB, free: 1.52 MB / 0.698 GB Notification: Performance of matching and sorting (n=282): time 0.009844/0.6047, allocations: 10.19 MB / 1.033 GB, free: 10.54 MB / 0.7137 GB Notification: Performance of inlineWhenForInitialization (initialization): time 0.0004782/0.6052, allocations: 1.652 MB / 1.035 GB, free: 8.598 MB / 0.7137 GB Notification: Performance of selectInitializationVariablesDAE (initialization): time 0.001117/0.6063, allocations: 1.206 MB / 1.036 GB, free: 8.098 MB / 0.7137 GB Notification: Performance of collectPreVariables (initialization): time 0.0001318/0.6064, allocations: 116.2 kB / 1.036 GB, free: 8.016 MB / 0.7137 GB Notification: Performance of collectInitialEqns (initialization): time 0.0003849/0.6068, allocations: 0.712 MB / 1.037 GB, free: 7.453 MB / 0.7137 GB Notification: Performance of collectInitialBindings (initialization): time 0.0005283/0.6073, allocations: 0.9141 MB / 1.038 GB, free: 6.75 MB / 0.7137 GB Notification: Performance of simplifyInitialFunctions (initialization): time 0.0005061/0.6078, allocations: 483 kB / 1.038 GB, free: 6.535 MB / 0.7137 GB Notification: Performance of setup shared object (initialization): time 6.831e-05/0.6079, allocations: 301.1 kB / 1.039 GB, free: 6.238 MB / 0.7137 GB Notification: Performance of preBalanceInitialSystem (initialization): time 0.00147/0.6094, allocations: 1.629 MB / 1.04 GB, free: 5.07 MB / 0.7137 GB Notification: Performance of partitionIndependentBlocks (initialization): time 0.001787/0.6112, allocations: 2.429 MB / 1.043 GB, free: 2.727 MB / 0.7137 GB Notification: Performance of analyzeInitialSystem (initialization): time 0.005674/0.6168, allocations: 6.586 MB / 1.049 GB, free: 13.14 MB / 0.7293 GB Notification: Performance of solveInitialSystemEqSystem (initialization): time 1.333e-05/0.6169, allocations: 7.062 kB / 1.049 GB, free: 13.14 MB / 0.7293 GB Notification: Performance of matching and sorting (n=426) (initialization): time 0.00407/0.6209, allocations: 4.497 MB / 1.053 GB, free: 10.06 MB / 0.7293 GB Notification: Performance of prepare postOptimizeDAE: time 0.0002287/0.6212, allocations: 0.6735 MB / 1.054 GB, free: 9.27 MB / 0.7293 GB Notification: Performance of postOpt simplifyComplexFunction (initialization): time 2.233e-05/0.6212, allocations: 25.53 kB / 1.054 GB, free: 9.266 MB / 0.7293 GB Notification: Performance of postOpt tearingSystem (initialization): time 3.661e-05/0.6212, allocations: 36.22 kB / 1.054 GB, free: 9.266 MB / 0.7293 GB Notification: Performance of postOpt solveSimpleEquations (initialization): time 0.001174/0.6224, allocations: 0.6171 MB / 1.055 GB, free: 9.109 MB / 0.7293 GB Notification: Performance of postOpt calculateStrongComponentJacobians (initialization): time 3.572e-05/0.6224, allocations: 51.83 kB / 1.055 GB, free: 9.094 MB / 0.7293 GB Notification: Performance of postOpt simplifyAllExpressions (initialization): time 0.0008608/0.6233, allocations: 153.4 kB / 1.055 GB, free: 9.02 MB / 0.7293 GB Notification: Performance of postOpt collapseArrayExpressions (initialization): time 0.0001404/0.6234, allocations: 135.8 kB / 1.055 GB, free: 8.988 MB / 0.7293 GB Warning: Assuming fixed start value for the following 84 variables: ref_low.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref_low.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref_low.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref_low.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref_low.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref_high.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref_high.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref_high.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref_high.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref_high.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real ref.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real ref.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_low.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_low.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient_low.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_low.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient_low.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_high.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_high.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient_high.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient_high.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient_high.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient.central.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient.periodicDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient.periodicDose.absorptionLumen.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient.periodicDose.variableDose.TotalCumulativeMass:VARIABLE(min = -1e-12 unit = \"kg\" fixed = true ) \"Total dose adminitrated by this source\" type: Real patient.peripheral.AUC:VARIABLE(unit = \"kg.s/m3\" fixed = true ) \"area under curve\" type: Real patient.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_high.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient_low.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_high.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.peripheral.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.peripheral.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.periodicDose.absorptionLumen.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.periodicDose.absorptionLumen.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.central.Cmin:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real ref_low.central.Cmax:DISCRETE(min = -1e-9 unit = \"kg/m3\" fixed = true ) type: Real patient.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_high.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_high.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_high.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_low.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_low.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean patient_low.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_high.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_high.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_high.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_low.peripheral.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_low.periodicDose.absorptionLumen.rising:DISCRETE(fixed = true protected = true ) type: Boolean ref_low.central.rising:DISCRETE(fixed = true protected = true ) type: Boolean Notification: Model statistics after passing the back-end for initialization: * Number of independent subsystems: 96 * Number of states: 0 () * Number of discrete variables: 174 ($PRE.patient.peripheral.Cmin,patient.peripheral.Cmin,$PRE.patient.peripheral.Cmax,patient.peripheral.Cmax,$PRE.patient.periodicDose.absorptionLumen.Cmin,patient.periodicDose.absorptionLumen.Cmin,$PRE.patient.periodicDose.absorptionLumen.Cmax,patient.periodicDose.absorptionLumen.Cmax,$PRE.patient.central.Cmin,patient.central.Cmin,$PRE.patient.central.Cmax,patient.central.Cmax,$PRE.patient_high.peripheral.Cmin,patient_high.peripheral.Cmin,$PRE.patient_high.peripheral.Cmax,patient_high.peripheral.Cmax,$PRE.patient_high.periodicDose.absorptionLumen.Cmin,patient_high.periodicDose.absorptionLumen.Cmin,$PRE.patient_high.periodicDose.absorptionLumen.Cmax,patient_high.periodicDose.absorptionLumen.Cmax,$PRE.patient_high.central.Cmin,patient_high.central.Cmin,$PRE.patient_high.central.Cmax,patient_high.central.Cmax,$PRE.patient_low.peripheral.Cmin,patient_low.peripheral.Cmin,$PRE.patient_low.peripheral.Cmax,patient_low.peripheral.Cmax,$PRE.patient_low.periodicDose.absorptionLumen.Cmin,patient_low.periodicDose.absorptionLumen.Cmin,$PRE.patient_low.periodicDose.absorptionLumen.Cmax,patient_low.periodicDose.absorptionLumen.Cmax,$PRE.patient_low.central.Cmin,patient_low.central.Cmin,$PRE.patient_low.central.Cmax,patient_low.central.Cmax,$PRE.ref.peripheral.Cmin,ref.peripheral.Cmin,$PRE.ref.peripheral.Cmax,ref.peripheral.Cmax,$PRE.ref.periodicDose.absorptionLumen.Cmin,ref.periodicDose.absorptionLumen.Cmin,$PRE.ref.periodicDose.absorptionLumen.Cmax,ref.periodicDose.absorptionLumen.Cmax,$PRE.ref.central.Cmin,ref.central.Cmin,$PRE.ref.central.Cmax,ref.central.Cmax,$PRE.ref_high.peripheral.Cmin,ref_high.peripheral.Cmin,$PRE.ref_high.peripheral.Cmax,ref_high.peripheral.Cmax,$PRE.ref_high.periodicDose.absorptionLumen.Cmin,ref_high.periodicDose.absorptionLumen.Cmin,$PRE.ref_high.periodicDose.absorptionLumen.Cmax,ref_high.periodicDose.absorptionLumen.Cmax,$PRE.ref_high.central.Cmin,ref_high.central.Cmin,$PRE.ref_high.central.Cmax,ref_high.central.Cmax,$PRE.ref_low.peripheral.Cmin,ref_low.peripheral.Cmin,$PRE.ref_low.peripheral.Cmax,ref_low.peripheral.Cmax,$PRE.ref_low.periodicDose.absorptionLumen.Cmin,ref_low.periodicDose.absorptionLumen.Cmin,$PRE.ref_low.periodicDose.absorptionLumen.Cmax,ref_low.periodicDose.absorptionLumen.Cmax,$PRE.ref_low.central.Cmin,ref_low.central.Cmin,$PRE.ref_low.central.Cmax,ref_low.central.Cmax,$PRE.patient.peripheral.rising,$PRE.patient.periodicDose.pulse.count,$PRE.patient.periodicDose.pulse.T_start,$PRE.patient.periodicDose.absorptionLumen.rising,$PRE.patient.central.rising,patient.peripheral.rising,patient.periodicDose.pulse.count,patient.periodicDose.pulse.T_start,patient.periodicDose.absorptionLumen.rising,patient.central.rising,$whenCondition41,$whenCondition40,$whenCondition39,$whenCondition38,$whenCondition37,$whenCondition36,$whenCondition42,$PRE.patient_high.peripheral.rising,$PRE.patient_high.periodicDose.pulse.count,$PRE.patient_high.periodicDose.pulse.T_start,$PRE.patient_high.periodicDose.absorptionLumen.rising,$PRE.patient_high.central.rising,patient_high.peripheral.rising,patient_high.periodicDose.pulse.count,patient_high.periodicDose.pulse.T_start,patient_high.periodicDose.absorptionLumen.rising,patient_high.central.rising,$whenCondition34,$whenCondition33,$whenCondition32,$whenCondition31,$whenCondition30,$whenCondition29,$whenCondition35,$PRE.patient_low.peripheral.rising,$PRE.patient_low.periodicDose.pulse.count,$PRE.patient_low.periodicDose.pulse.T_start,$PRE.patient_low.periodicDose.absorptionLumen.rising,$PRE.patient_low.central.rising,patient_low.peripheral.rising,patient_low.periodicDose.pulse.count,patient_low.periodicDose.pulse.T_start,patient_low.periodicDose.absorptionLumen.rising,patient_low.central.rising,$whenCondition27,$whenCondition26,$whenCondition25,$whenCondition24,$whenCondition23,$whenCondition22,$whenCondition28,$PRE.ref.peripheral.rising,$PRE.ref.periodicDose.pulse.count,$PRE.ref.periodicDose.pulse.T_start,$PRE.ref.periodicDose.absorptionLumen.rising,$PRE.ref.central.rising,ref.peripheral.rising,ref.periodicDose.pulse.count,ref.periodicDose.pulse.T_start,ref.periodicDose.absorptionLumen.rising,ref.central.rising,$whenCondition20,$whenCondition19,$whenCondition18,$whenCondition17,$whenCondition16,$whenCondition15,$whenCondition21,$PRE.ref_high.peripheral.rising,$PRE.ref_high.periodicDose.pulse.count,$PRE.ref_high.periodicDose.pulse.T_start,$PRE.ref_high.periodicDose.absorptionLumen.rising,$PRE.ref_high.central.rising,ref_high.peripheral.rising,ref_high.periodicDose.pulse.count,ref_high.periodicDose.pulse.T_start,ref_high.periodicDose.absorptionLumen.rising,ref_high.central.rising,$whenCondition13,$whenCondition12,$whenCondition11,$whenCondition10,$whenCondition9,$whenCondition8,$whenCondition14,$PRE.ref_low.peripheral.rising,$PRE.ref_low.periodicDose.pulse.count,$PRE.ref_low.periodicDose.pulse.T_start,$PRE.ref_low.periodicDose.absorptionLumen.rising,$PRE.ref_low.central.rising,ref_low.peripheral.rising,ref_low.periodicDose.pulse.count,ref_low.periodicDose.pulse.T_start,ref_low.periodicDose.absorptionLumen.rising,ref_low.central.rising,$whenCondition6,$whenCondition5,$whenCondition4,$whenCondition3,$whenCondition2,$whenCondition1,$whenCondition7) * Number of discrete states: 0 () * Number of clocked states: 0 () * Top-level inputs: 0 Notification: Strong component statistics for initialization (402): * Single equations (assignments): 378 * Array equations: 0 * Algorithm blocks: 24 * Record equations: 0 * When equations: 0 * If-equations: 0 * Equation systems (not torn): 0 * Torn equation systems: 0 * Mixed (continuous/discrete) equation systems: 0 Notification: Performance of prepare postOptimizeDAE: time 0.001153/0.6246, allocations: 1.4 MB / 1.056 GB, free: 7.785 MB / 0.7293 GB Notification: Performance of postOpt lateInlineFunction (simulation): time 0.0002315/0.6248, allocations: 234 kB / 1.057 GB, free: 7.668 MB / 0.7293 GB Notification: Performance of postOpt wrapFunctionCalls (simulation): time 0.0001988/0.625, allocations: 208.7 kB / 1.057 GB, free: 7.504 MB / 0.7293 GB Notification: Performance of postOpt inlineArrayEqn (simulation): time 1.183e-05/0.625, allocations: 23 kB / 1.057 GB, free: 7.504 MB / 0.7293 GB Notification: Performance of postOpt constantLinearSystem (simulation): time 2.563e-05/0.625, allocations: 5.594 kB / 1.057 GB, free: 7.5 MB / 0.7293 GB Notification: Performance of postOpt simplifysemiLinear (simulation): time 1.403e-05/0.6251, allocations: 13.67 kB / 1.057 GB, free: 7.488 MB / 0.7293 GB Notification: Performance of postOpt removeSimpleEquations (simulation): time 0.005919/0.631, allocations: 5.951 MB / 1.063 GB, free: 3.348 MB / 0.7293 GB Notification: Performance of postOpt simplifyComplexFunction (simulation): time 5.41e-06/0.631, allocations: 1.281 kB / 1.063 GB, free: 3.348 MB / 0.7293 GB Notification: Performance of postOpt solveSimpleEquations (simulation): time 0.001199/0.6322, allocations: 454 kB / 1.063 GB, free: 3.23 MB / 0.7293 GB Notification: Performance of postOpt tearingSystem (simulation): time 1.836e-05/0.6322, allocations: 9.219 kB / 1.063 GB, free: 3.23 MB / 0.7293 GB Notification: Performance of postOpt inputDerivativesUsed (simulation): time 0.0001599/0.6324, allocations: 93.83 kB / 1.063 GB, free: 3.18 MB / 0.7293 GB Notification: Performance of postOpt calculateStrongComponentJacobians (simulation): time 1.187e-05/0.6324, allocations: 11.78 kB / 1.063 GB, free: 3.176 MB / 0.7293 GB Notification: Performance of postOpt calculateStateSetsJacobians (simulation): time 3.687e-06/0.6324, allocations: 6.188 kB / 1.063 GB, free: 3.172 MB / 0.7293 GB Notification: Performance of postOpt symbolicJacobian (simulation): time 0.005612/0.638, allocations: 5.896 MB / 1.069 GB, free: 14.96 MB / 0.7449 GB Notification: Performance of postOpt removeConstants (simulation): time 0.000623/0.6386, allocations: 435.2 kB / 1.069 GB, free: 14.63 MB / 0.7449 GB Notification: Performance of postOpt simplifyTimeIndepFuncCalls (simulation): time 0.0003101/0.6389, allocations: 115.1 kB / 1.07 GB, free: 14.57 MB / 0.7449 GB Notification: Performance of postOpt simplifyAllExpressions (simulation): time 0.0007138/0.6396, allocations: 114.2 kB / 1.07 GB, free: 14.52 MB / 0.7449 GB Notification: Performance of postOpt findZeroCrossings (simulation): time 0.0003359/0.64, allocations: 257.5 kB / 1.07 GB, free: 14.35 MB / 0.7449 GB Notification: Performance of postOpt collapseArrayExpressions (simulation): time 0.0001121/0.6401, allocations: 95.52 kB / 1.07 GB, free: 14.32 MB / 0.7449 GB Notification: Performance of sorting global known variables: time 0.0007663/0.6409, allocations: 0.7903 MB / 1.071 GB, free: 13.88 MB / 0.7449 GB Notification: Performance of sort global known variables: time 9e-08/0.6409, allocations: 3.938 kB / 1.071 GB, free: 13.88 MB / 0.7449 GB Notification: Performance of remove unused functions: time 0.001177/0.642, allocations: 0.653 MB / 1.071 GB, free: 13.8 MB / 0.7449 GB Notification: Model statistics after passing the back-end for simulation: * Number of independent subsystems: 6 * Number of states: 54 (ref_low.central.C,ref_low.central.AUC,ref_low.elim.MExc,ref_low.periodicDose.TotalCumulativeMass,ref_low.periodicDose.absorptionLumen.C,ref_low.periodicDose.absorptionLumen.AUC,ref_low.periodicDose.variableDose.TotalCumulativeMass,ref_low.peripheral.C,ref_low.peripheral.AUC,ref_high.central.C,ref_high.central.AUC,ref_high.elim.MExc,ref_high.periodicDose.TotalCumulativeMass,ref_high.periodicDose.absorptionLumen.C,ref_high.periodicDose.absorptionLumen.AUC,ref_high.periodicDose.variableDose.TotalCumulativeMass,ref_high.peripheral.C,ref_high.peripheral.AUC,ref.central.C,ref.central.AUC,ref.elim.MExc,ref.periodicDose.TotalCumulativeMass,ref.periodicDose.absorptionLumen.C,ref.periodicDose.absorptionLumen.AUC,ref.periodicDose.variableDose.TotalCumulativeMass,ref.peripheral.C,ref.peripheral.AUC,patient_low.central.C,patient_low.central.AUC,patient_low.elim.MExc,patient_low.periodicDose.TotalCumulativeMass,patient_low.periodicDose.absorptionLumen.C,patient_low.periodicDose.absorptionLumen.AUC,patient_low.periodicDose.variableDose.TotalCumulativeMass,patient_low.peripheral.C,patient_low.peripheral.AUC,patient_high.central.C,patient_high.central.AUC,patient_high.elim.MExc,patient_high.periodicDose.TotalCumulativeMass,patient_high.periodicDose.absorptionLumen.C,patient_high.periodicDose.absorptionLumen.AUC,patient_high.periodicDose.variableDose.TotalCumulativeMass,patient_high.peripheral.C,patient_high.peripheral.AUC,patient.central.C,patient.central.AUC,patient.elim.MExc,patient.periodicDose.TotalCumulativeMass,patient.periodicDose.absorptionLumen.C,patient.periodicDose.absorptionLumen.AUC,patient.periodicDose.variableDose.TotalCumulativeMass,patient.peripheral.C,patient.peripheral.AUC) * Number of discrete variables: 108 ($whenCondition7,$whenCondition1,$whenCondition2,$whenCondition3,$whenCondition4,$whenCondition5,$whenCondition6,ref_low.central.Cmax,ref_low.central.Cmin,ref_low.central.rising,ref_low.periodicDose.absorptionLumen.Cmax,ref_low.periodicDose.absorptionLumen.Cmin,ref_low.periodicDose.absorptionLumen.rising,ref_low.periodicDose.pulse.T_start,ref_low.periodicDose.pulse.count,ref_low.peripheral.Cmax,ref_low.peripheral.Cmin,ref_low.peripheral.rising,$whenCondition14,$whenCondition8,$whenCondition9,$whenCondition10,$whenCondition11,$whenCondition12,$whenCondition13,ref_high.central.Cmax,ref_high.central.Cmin,ref_high.central.rising,ref_high.periodicDose.absorptionLumen.Cmax,ref_high.periodicDose.absorptionLumen.Cmin,ref_high.periodicDose.absorptionLumen.rising,ref_high.periodicDose.pulse.T_start,ref_high.periodicDose.pulse.count,ref_high.peripheral.Cmax,ref_high.peripheral.Cmin,ref_high.peripheral.rising,$whenCondition21,$whenCondition15,$whenCondition16,$whenCondition17,$whenCondition18,$whenCondition19,$whenCondition20,ref.central.Cmax,ref.central.Cmin,ref.central.rising,ref.periodicDose.absorptionLumen.Cmax,ref.periodicDose.absorptionLumen.Cmin,ref.periodicDose.absorptionLumen.rising,ref.periodicDose.pulse.T_start,ref.periodicDose.pulse.count,ref.peripheral.Cmax,ref.peripheral.Cmin,ref.peripheral.rising,$whenCondition28,$whenCondition22,$whenCondition23,$whenCondition24,$whenCondition25,$whenCondition26,$whenCondition27,patient_low.central.Cmax,patient_low.central.Cmin,patient_low.central.rising,patient_low.periodicDose.absorptionLumen.Cmax,patient_low.periodicDose.absorptionLumen.Cmin,patient_low.periodicDose.absorptionLumen.rising,patient_low.periodicDose.pulse.T_start,patient_low.periodicDose.pulse.count,patient_low.peripheral.Cmax,patient_low.peripheral.Cmin,patient_low.peripheral.rising,$whenCondition35,$whenCondition29,$whenCondition30,$whenCondition31,$whenCondition32,$whenCondition33,$whenCondition34,patient_high.central.Cmax,patient_high.central.Cmin,patient_high.central.rising,patient_high.periodicDose.absorptionLumen.Cmax,patient_high.periodicDose.absorptionLumen.Cmin,patient_high.periodicDose.absorptionLumen.rising,patient_high.periodicDose.pulse.T_start,patient_high.periodicDose.pulse.count,patient_high.peripheral.Cmax,patient_high.peripheral.Cmin,patient_high.peripheral.rising,$whenCondition42,$whenCondition36,$whenCondition37,$whenCondition38,$whenCondition39,$whenCondition40,$whenCondition41,patient.central.Cmax,patient.central.Cmin,patient.central.rising,patient.periodicDose.absorptionLumen.Cmax,patient.periodicDose.absorptionLumen.Cmin,patient.periodicDose.absorptionLumen.rising,patient.periodicDose.pulse.T_start,patient.periodicDose.pulse.count,patient.peripheral.Cmax,patient.peripheral.Cmin,patient.peripheral.rising) * Number of discrete states: 96 (patient.periodicDose.pulse.count,patient.peripheral.Cmin,$whenCondition41,patient.peripheral.Cmax,$whenCondition40,patient.peripheral.rising,patient.periodicDose.absorptionLumen.Cmin,$whenCondition39,patient.periodicDose.absorptionLumen.Cmax,$whenCondition38,patient.periodicDose.absorptionLumen.rising,patient.central.Cmin,$whenCondition37,patient.central.Cmax,$whenCondition36,patient.central.rising,patient_high.periodicDose.pulse.count,patient_high.peripheral.Cmin,$whenCondition34,patient_high.peripheral.Cmax,$whenCondition33,patient_high.peripheral.rising,patient_high.periodicDose.absorptionLumen.Cmin,$whenCondition32,patient_high.periodicDose.absorptionLumen.Cmax,$whenCondition31,patient_high.periodicDose.absorptionLumen.rising,patient_high.central.Cmin,$whenCondition30,patient_high.central.Cmax,$whenCondition29,patient_high.central.rising,patient_low.periodicDose.pulse.count,patient_low.peripheral.Cmin,$whenCondition27,patient_low.peripheral.Cmax,$whenCondition26,patient_low.peripheral.rising,patient_low.periodicDose.absorptionLumen.Cmin,$whenCondition25,patient_low.periodicDose.absorptionLumen.Cmax,$whenCondition24,patient_low.periodicDose.absorptionLumen.rising,patient_low.central.Cmin,$whenCondition23,patient_low.central.Cmax,$whenCondition22,patient_low.central.rising,ref.periodicDose.pulse.count,ref.peripheral.Cmin,$whenCondition20,ref.peripheral.Cmax,$whenCondition19,ref.peripheral.rising,ref.periodicDose.absorptionLumen.Cmin,$whenCondition18,ref.periodicDose.absorptionLumen.Cmax,$whenCondition17,ref.periodicDose.absorptionLumen.rising,ref.central.Cmin,$whenCondition16,ref.central.Cmax,$whenCondition15,ref.central.rising,ref_high.periodicDose.pulse.count,ref_high.peripheral.Cmin,$whenCondition13,ref_high.peripheral.Cmax,$whenCondition12,ref_high.peripheral.rising,ref_high.periodicDose.absorptionLumen.Cmin,$whenCondition11,ref_high.periodicDose.absorptionLumen.Cmax,$whenCondition10,ref_high.periodicDose.absorptionLumen.rising,ref_high.central.Cmin,$whenCondition9,ref_high.central.Cmax,$whenCondition8,ref_high.central.rising,ref_low.periodicDose.pulse.count,ref_low.peripheral.Cmin,$whenCondition6,ref_low.peripheral.Cmax,$whenCondition5,ref_low.peripheral.rising,ref_low.periodicDose.absorptionLumen.Cmin,$whenCondition4,ref_low.periodicDose.absorptionLumen.Cmax,$whenCondition3,ref_low.periodicDose.absorptionLumen.rising,ref_low.central.Cmin,$whenCondition2,ref_low.central.Cmax,$whenCondition1,ref_low.central.rising) * Number of clocked states: 0 () * Top-level inputs: 0 Notification: Strong component statistics for simulation (228): * Single equations (assignments): 198 * Array equations: 0 * Algorithm blocks: 18 * Record equations: 0 * When equations: 12 * If-equations: 0 * Equation systems (not torn): 0 * Torn equation systems: 0 * Mixed (continuous/discrete) equation systems: 0 Notification: Performance of Backend phase and start with SimCode phase: time 0.0003098/0.6423, allocations: 350.7 kB / 1.072 GB, free: 13.57 MB / 0.7449 GB Notification: Performance of simCode: created initialization part: time 0.003851/0.6462, allocations: 4.835 MB / 1.077 GB, free: 9.543 MB / 0.7449 GB Notification: Performance of simCode: created event and clocks part: time 2.224e-06/0.6462, allocations: 0 / 1.077 GB, free: 9.543 MB / 0.7449 GB Notification: Performance of simCode: created simulation system equations: time 0.001904/0.6481, allocations: 2.727 MB / 1.079 GB, free: 6.922 MB / 0.7449 GB Notification: Performance of simCode: created of all other equations (e.g. parameter, nominal, assert, etc): time 0.001916/0.65, allocations: 0.6904 MB / 1.08 GB, free: 6.242 MB / 0.7449 GB Notification: Performance of simCode: created linear, non-linear and system jacobian parts: time 0.006798/0.6568, allocations: 7.21 MB / 1.087 GB, free: 14.89 MB / 0.7605 GB Notification: Performance of simCode: some other stuff during SimCode phase: time 0.0006183/0.6574, allocations: 0.8779 MB / 1.088 GB, free: 13.97 MB / 0.7605 GB Notification: Performance of simCode: all other stuff during SimCode phase: time 0.0003542/0.6578, allocations: 167.4 kB / 1.088 GB, free: 13.8 MB / 0.7605 GB Notification: Performance of SimCode: time 6.71e-07/0.6578, allocations: 0 / 1.088 GB, free: 13.8 MB / 0.7605 GB Notification: Performance of Templates: time 0.02662/0.6844, allocations: 31.45 MB / 1.119 GB, free: 14.57 MB / 0.7918 GB " [Timeout remaining time 659] make -j1 -f Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.makefile [Timeout 660] (rm -f Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.pipe ; mkfifo Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.pipe ; head -c 1048576 < Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.pipe >> ../files/Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.sim & ./Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic > Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic.pipe 2>&1) [Timeout 240] [Calling sys.exit(0), Time elapsed: 8.94025633810088]