Running command: translateModel(BioChem.Examples.centralMetabolism.extra_cellular,tolerance=1e-05,outputFormat="empty",numberOfIntervals=5000,variableFilter="",fileNamePrefix="BioChem_BioChem.Examples.centralMetabolism.extra_cellular")
Notification: Performance of loadModel(BioChem): time 1.967/1.967, allocations: 217.9 MB / 230.1 MB, free: 14.38 MB / 202.7 MB
Warning: Ignoring unknown experiment annotation option: Algorithm = "dassl"
Notification: Performance of FrontEnd - loaded program: time 3.141e-05/3.159e-05, allocations: 3.938 kB / 283.4 MB, free: 9.648 MB / 234.7 MB
Notification: Performance of FrontEnd - Absyn->SCode: time 0.09195/0.092, allocations: 50.42 MB / 333.8 MB, free: 7.133 MB / 282.7 MB
Notification: Performance of FrontEnd - scodeFlatten: time 0.3762/0.4683, allocations: 94.33 MB / 428.1 MB, free: 1.34 MB / 346.7 MB
Notification: Performance of FrontEnd - mkProgramGraph: time 0.0001663/0.4685, allocations: 59.09 kB / 428.2 MB, free: 1.312 MB / 346.7 MB
Notification: Performance of FrontEnd - DAE generated: time 0.1431/0.6116, allocations: 39.34 MB / 467.5 MB, free: 14.95 MB / 394.7 MB
Notification: Performance of FrontEnd: time 2.289e-06/0.6116, allocations: 0 / 467.5 MB, free: 14.95 MB / 394.7 MB
Notification: Performance of Transformations before backend: time 5.006e-05/0.6117, allocations: 24 kB / 467.5 MB, free: 14.93 MB / 394.7 MB
Notification: Model statistics after passing the front-end and creating the data structures used by the back-end:
 * Number of equations: 353
 * Number of variables: 353
Notification: Performance of Generate backend data structure: time 0.003126/0.6148, allocations: 1.234 MB / 468.8 MB, free: 13.64 MB / 394.7 MB
Notification: Performance of prepare preOptimizeDAE: time 4.604e-05/0.6149, allocations: 8.031 kB / 468.8 MB, free: 13.64 MB / 394.7 MB
Notification: Performance of preOpt normalInlineFunction (simulation): time 0.0003875/0.6153, allocations: 134.4 kB / 468.9 MB, free: 13.5 MB / 394.7 MB
Notification: Performance of preOpt evaluateParameters (simulation): time 0.001064/0.6164, allocations: 0.5361 MB / 469.4 MB, free: 12.93 MB / 394.7 MB
Notification: Performance of preOpt simplifyIfEquations (simulation): time 0.0001117/0.6165, allocations: 102.8 kB / 469.5 MB, free: 12.82 MB / 394.7 MB
Notification: Performance of preOpt expandDerOperator (simulation): time 0.0002881/0.6168, allocations: 143.9 kB / 469.7 MB, free: 12.68 MB / 394.7 MB
Notification: Performance of preOpt clockPartitioning (simulation): time 0.003167/0.62, allocations: 1.263 MB / 471 MB, free: 11.39 MB / 394.7 MB
Notification: Performance of preOpt findStateOrder (simulation): time 5.832e-05/0.6201, allocations: 7.906 kB / 471 MB, free: 11.38 MB / 394.7 MB
Notification: Performance of preOpt replaceEdgeChange (simulation): time 0.00018/0.6203, allocations: 60 kB / 471 MB, free: 11.32 MB / 394.7 MB
Notification: Performance of preOpt inlineArrayEqn (simulation): time 4.072e-05/0.6203, allocations: 35.94 kB / 471.1 MB, free: 11.29 MB / 394.7 MB
Notification: Performance of preOpt removeEqualRHS (simulation): time 0.002805/0.6231, allocations: 1.025 MB / 472.1 MB, free: 10.26 MB / 394.7 MB
Notification: Performance of preOpt removeSimpleEquations (simulation): time 0.01036/0.6335, allocations: 4.389 MB / 476.5 MB, free: 5.75 MB / 394.7 MB
Notification: Performance of preOpt comSubExp (simulation): time 0.002455/0.636, allocations: 1.594 MB / 478.1 MB, free: 3.984 MB / 394.7 MB
Notification: Performance of preOpt resolveLoops (simulation): time 0.001054/0.6371, allocations: 474.4 kB / 478.5 MB, free: 3.52 MB / 394.7 MB
Notification: Performance of preOpt evalFunc (simulation): time 7.826e-05/0.6372, allocations: 16.67 kB / 478.5 MB, free: 3.5 MB / 394.7 MB
Notification: Performance of preOpt encapsulateWhenConditions (simulation): time 4.825e-05/0.6372, allocations: 47.34 kB / 478.6 MB, free: 3.445 MB / 394.7 MB
Notification: Performance of pre-optimization done (n=96): time 6.27e-06/0.6373, allocations: 3.938 kB / 478.6 MB, free: 3.441 MB / 394.7 MB
Notification: Performance of matching and sorting (n=114): time 0.0159/0.6532, allocations: 4.219 MB / 482.8 MB, free: 15.2 MB / 410.7 MB
Notification: Performance of inlineWhenForInitialization (initialization): time 5.549e-05/0.6533, allocations: 64.41 kB / 482.9 MB, free: 15.12 MB / 410.7 MB
Notification: Performance of selectInitializationVariablesDAE (initialization): time 0.0005014/0.6538, allocations: 322.7 kB / 483.2 MB, free: 14.8 MB / 410.7 MB
Notification: Performance of collectPreVariables (initialization): time 0.0001035/0.6539, allocations: 45.7 kB / 483.2 MB, free: 14.75 MB / 410.7 MB
Notification: Performance of collectInitialEqns (initialization): time 0.0004224/0.6543, allocations: 0.522 MB / 483.8 MB, free: 14.22 MB / 410.7 MB
Notification: Performance of collectInitialBindings (initialization): time 0.0004465/0.6548, allocations: 410 kB / 484.2 MB, free: 13.82 MB / 410.7 MB
Notification: Performance of simplifyInitialFunctions (initialization): time 8.987e-05/0.6549, allocations: 28 kB / 484.2 MB, free: 13.79 MB / 410.7 MB
Notification: Performance of setup shared object (initialization): time 0.0002464/0.6552, allocations: 378.8 kB / 484.6 MB, free: 13.41 MB / 410.7 MB
Notification: Performance of preBalanceInitialSystem (initialization): time 0.0009956/0.6562, allocations: 386.6 kB / 484.9 MB, free: 13.04 MB / 410.7 MB
Notification: Performance of partitionIndependentBlocks (initialization): time 0.001229/0.6574, allocations: 0.6342 MB / 485.6 MB, free: 12.29 MB / 410.7 MB
Notification: Performance of analyzeInitialSystem (initialization): time 0.001257/0.6587, allocations: 0.518 MB / 486.1 MB, free: 11.77 MB / 410.7 MB
Notification: Performance of solveInitialSystemEqSystem (initialization): time 1.486e-05/0.6587, allocations: 0 / 486.1 MB, free: 11.77 MB / 410.7 MB
Notification: Performance of matching and sorting (n=165) (initialization): time 0.003514/0.6622, allocations: 1.338 MB / 487.4 MB, free: 10.42 MB / 410.7 MB
Notification: Performance of prepare postOptimizeDAE: time 3.039e-05/0.6623, allocations: 11.98 kB / 487.4 MB, free: 10.41 MB / 410.7 MB
Notification: Performance of postOpt simplifyComplexFunction (initialization): time 1.826e-05/0.6623, allocations: 8 kB / 487.4 MB, free: 10.4 MB / 410.7 MB
Notification: Performance of postOpt tearingSystem (initialization): time 0.0006225/0.663, allocations: 129.8 kB / 487.6 MB, free: 10.27 MB / 410.7 MB
Notification: Performance of postOpt solveSimpleEquations (initialization): time 0.001718/0.6647, allocations: 287.6 kB / 487.8 MB, free: 9.988 MB / 410.7 MB
Notification: Performance of postOpt calculateStrongComponentJacobians (initialization): time 0.004039/0.6688, allocations: 3.146 MB / 491 MB, free: 6.57 MB / 410.7 MB
Notification: Performance of postOpt simplifyAllExpressions (initialization): time 0.001082/0.6699, allocations: 59.94 kB / 491.1 MB, free: 6.512 MB / 410.7 MB
Notification: Performance of postOpt collapseArrayExpressions (initialization): time 0.0001314/0.67, allocations: 44 kB / 491.1 MB, free: 6.469 MB / 410.7 MB
Warning: Assuming fixed start value for the following 17 variables:
         LACext.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.G3P.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.mitochondria.NADm.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.mitochondria.NADHm.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.mitochondria.V:VARIABLE(start = 2.0 unit = "l" stateSelect=StateSelect.prefer )  "Compartment volume" type: Real
         cytosol.F6P.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.GLY.c:VARIABLE(min = max(0.0, max(0.0, 0.0)) start = 1.0 unit = "mol/l" stateSelect=StateSelect.prefer )  "Current concentration of substance (mM)" type: Real
         cytosol.CP.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.LAC.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.AMP.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.IMP.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.ADP.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.PYR.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         V:VARIABLE(start = 2.0 unit = "l" stateSelect=StateSelect.prefer )  "Compartment volume" type: Real
         cytosol.V:VARIABLE(start = 2.0 unit = "l" stateSelect=StateSelect.prefer )  "Compartment volume" type: Real
         cytosol.NADH.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
         cytosol.FDP.n:VARIABLE(min = 0.0 unit = "mol" stateSelect=StateSelect.prefer )  "Number of moles of substance in pool (mol)" type: Real
Notification: Model statistics after passing the back-end for initialization:
 * Number of independent subsystems: 35
 * Number of states: 0 ()
 * Number of discrete variables: 0 ()
 * Number of discrete states: 0 ()
 * Top-level inputs: 0
Notification: Strong component statistics for initialization (157):
 * Single equations (assignments): 155
 * Array equations: 0
 * Algorithm blocks: 0
 * Record equations: 0
 * When equations: 0
 * If-equations: 0
 * Equation systems (linear and non-linear blocks): 0
 * Torn equation systems: 2
 * Mixed (continuous/discrete) equation systems: 0
Notification: Torn system details for strict tearing set:
 * Linear torn systems: 2 {(1,100.0%) 4,(1,100.0%) 4}
 * Non-linear torn systems: 0
Notification: Performance of prepare postOptimizeDAE: time 0.0004985/0.6705, allocations: 248.6 kB / 491.3 MB, free: 6.223 MB / 410.7 MB
Notification: Performance of postOpt lateInlineFunction (simulation): time 0.0001971/0.6708, allocations: 67.25 kB / 491.4 MB, free: 6.156 MB / 410.7 MB
Notification: Performance of postOpt wrapFunctionCalls (simulation): time 0.0003026/0.6711, allocations: 119.1 kB / 491.5 MB, free: 6.035 MB / 410.7 MB
Notification: Performance of postOpt inlineArrayEqn (simulation): time 1.396e-05/0.6711, allocations: 12 kB / 491.5 MB, free: 6.023 MB / 410.7 MB
Notification: Performance of postOpt constantLinearSystem (simulation): time 1.289e-05/0.6711, allocations: 0 / 491.5 MB, free: 6.023 MB / 410.7 MB
Notification: Performance of postOpt simplifysemiLinear (simulation): time 1.591e-05/0.6712, allocations: 11.97 kB / 491.5 MB, free: 6.012 MB / 410.7 MB
Notification: Performance of postOpt removeSimpleEquations (simulation): time 0.00618/0.6773, allocations: 2.542 MB / 494.1 MB, free: 3.41 MB / 410.7 MB
Notification: Performance of postOpt simplifyComplexFunction (simulation): time 7.335e-06/0.6774, allocations: 0 / 494.1 MB, free: 3.41 MB / 410.7 MB
Notification: Performance of postOpt solveSimpleEquations (simulation): time 0.0017/0.6791, allocations: 215.7 kB / 494.3 MB, free: 3.199 MB / 410.7 MB
Notification: Performance of postOpt tearingSystem (simulation): time 0.0005831/0.6797, allocations: 121.6 kB / 494.4 MB, free: 3.074 MB / 410.7 MB
Notification: Performance of postOpt inputDerivativesUsed (simulation): time 0.0001233/0.6799, allocations: 31.92 kB / 494.4 MB, free: 3.043 MB / 410.7 MB
Notification: Performance of postOpt calculateStrongComponentJacobians (simulation): time 0.003995/0.6839, allocations: 3.13 MB / 497.6 MB, free: 15.65 MB / 426.7 MB
Notification: Performance of postOpt calculateStateSetsJacobians (simulation): time 2.834e-06/0.6839, allocations: 0 / 497.6 MB, free: 15.65 MB / 426.7 MB
Notification: Performance of postOpt symbolicJacobian (simulation): time 0.004299/0.6882, allocations: 1.735 MB / 499.3 MB, free: 13.88 MB / 426.7 MB
Notification: Performance of postOpt removeConstants (simulation): time 0.0002641/0.6885, allocations: 132.4 kB / 499.4 MB, free: 13.73 MB / 426.7 MB
Notification: Performance of postOpt simplifyTimeIndepFuncCalls (simulation): time 0.000157/0.6887, allocations: 27.94 kB / 499.5 MB, free: 13.71 MB / 426.7 MB
Notification: Performance of postOpt simplifyAllExpressions (simulation): time 0.0007397/0.6894, allocations: 47.92 kB / 499.5 MB, free: 13.66 MB / 426.7 MB
Notification: Performance of postOpt findZeroCrossings (simulation): time 0.0001838/0.6896, allocations: 72.84 kB / 499.6 MB, free: 13.59 MB / 426.7 MB
Notification: Performance of postOpt collapseArrayExpressions (simulation): time 0.0001078/0.6898, allocations: 31.98 kB / 499.6 MB, free: 13.55 MB / 426.7 MB
Notification: Performance of sorting global known variables: time 0.0003862/0.6902, allocations: 237.2 kB / 499.8 MB, free: 13.32 MB / 426.7 MB
Notification: Performance of sort global known variables: time 8.13e-07/0.6902, allocations: 7.938 kB / 499.9 MB, free: 13.32 MB / 426.7 MB
Notification: Performance of remove unused functions: time 0.001441/0.6916, allocations: 280 kB / 0.4884 GB, free: 13.04 MB / 426.7 MB
Notification: Model statistics after passing the back-end for simulation:
 * Number of independent subsystems: 2
 * Number of states: 17 (V,cytosol.V,cytosol.NADH.n,cytosol.FDP.n,cytosol.PYR.n,cytosol.ADP.n,cytosol.IMP.n,cytosol.AMP.n,cytosol.LAC.n,cytosol.CP.n,cytosol.GLY.c,cytosol.F6P.n,cytosol.mitochondria.V,cytosol.mitochondria.NADHm.n,cytosol.mitochondria.NADm.n,cytosol.G3P.n,LACext.n)
 * Number of discrete variables: 0 ()
 * Number of discrete states: 0 ()
 * Top-level inputs: 0
Notification: Strong component statistics for simulation (106):
 * Single equations (assignments): 104
 * Array equations: 0
 * Algorithm blocks: 0
 * Record equations: 0
 * When equations: 0
 * If-equations: 0
 * Equation systems (linear and non-linear blocks): 0
 * Torn equation systems: 2
 * Mixed (continuous/discrete) equation systems: 0
Notification: Torn system details for strict tearing set:
 * Linear torn systems: 2 {(1,100.0%) 4,(1,100.0%) 4}
 * Non-linear torn systems: 0
Notification: Performance of Backend phase and start with SimCode phase: time 0.0002652/0.6919, allocations: 131.1 kB / 0.4885 GB, free: 12.91 MB / 426.7 MB
Notification: Performance of simCode: created initialization part: time 0.003049/0.695, allocations: 1.299 MB / 0.4898 GB, free: 11.59 MB / 426.7 MB
Notification: Performance of simCode: created event and clocks part: time 4.095e-06/0.695, allocations: 1.375 kB / 0.4898 GB, free: 11.59 MB / 426.7 MB
Notification: Performance of simCode: created simulation system equations: time 0.001614/0.6966, allocations: 0.7647 MB / 0.4905 GB, free: 10.8 MB / 426.7 MB
Notification: Performance of simCode: created of all other equations (e.g. parameter, nominal, assert, etc): time 0.0006856/0.6973, allocations: 91.48 kB / 0.4906 GB, free: 10.71 MB / 426.7 MB
Notification: Performance of simCode: created linear, non-linear and system jacobian parts: time 0.006634/0.704, allocations: 2.59 MB / 0.4932 GB, free: 8.09 MB / 426.7 MB
Notification: Performance of simCode: some other stuff during SimCode phase: time 0.00101/0.705, allocations: 1.088 MB / 0.4942 GB, free: 6.973 MB / 426.7 MB
Notification: Performance of simCode: alias equations: time 0.000896/0.706, allocations: 97.69 kB / 0.4943 GB, free: 6.875 MB / 426.7 MB
Notification: Performance of simCode: all other stuff during SimCode phase: time 0.0003774/0.7063, allocations: 59.42 kB / 0.4944 GB, free: 6.816 MB / 426.7 MB
Notification: Performance of SimCode: time 1.758e-06/0.7064, allocations: 0 / 0.4944 GB, free: 6.816 MB / 426.7 MB
Notification: Performance of Templates: time 0.02727/0.7336, allocations: 9.614 MB / 0.5038 GB, free: 13.23 MB / 442.7 MB