Environment - simulationEnvironment:
startTime=0
stopTime=86400
tolerance=1e-12
numberOfIntervals=864
stepSize=100
Regular simulation: ./Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_generic -abortSlowSimulation -alarm=240 -s gbode -gbm=radauIIA3 -lv LOG_STATS
LOG_STDOUT        | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used.
LOG_SUCCESS       | info    | The initialization finished successfully without homotopy method.
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable]
|                 | |       | The following assertion has been violated at time 900.000000
|                 | |       | ((ref_low.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref_low.periodicDose.absorptionLumen.M, has value: -1.20602e-10"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable]
|                 | |       | The following assertion has been violated at time 900.000000
|                 | |       | ((ref_low.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref_low.periodicDose.variableDose.TotalCumulativeMass, has value: -5.71153e-11"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable]
|                 | |       | The following assertion has been violated at time 959.944345
|                 | |       | ((ref.central.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= ref.central.C, has value: -1.60711e-09"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable]
|                 | |       | The following assertion has been violated at time 959.944345
|                 | |       | ((ref.central.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref.central.M, has value: -1.56211e-11"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable]
|                 | |       | The following assertion has been violated at time 959.944345
|                 | |       | ((ref.central.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= ref.central.Cmin, has value: -1.60711e-09"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable]
|                 | |       | The following assertion has been violated at time 959.944345
|                 | |       | ((ref.periodicDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref.periodicDose.TotalCumulativeMass, has value: -1.56213e-11"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable]
|                 | |       | The following assertion has been violated at time 959.944345
|                 | |       | ((ref.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref.periodicDose.variableDose.TotalCumulativeMass, has value: -1.57531e-11"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:20:3-20:56:writable]
|                 | |       | The following assertion has been violated at time 960.000000
|                 | |       | ((ref.central.Cmax >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= ref.central.Cmax, has value: -1.71077e-09"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable]
|                 | |       | The following assertion has been violated at time 960.000000
|                 | |       | ((ref.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= ref.periodicDose.absorptionLumen.C, has value: -1.77637e-09"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable]
|                 | |       | The following assertion has been violated at time 960.000000
|                 | |       | ((ref.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref.periodicDose.absorptionLumen.M, has value: -1.77637e-09"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable]
|                 | |       | The following assertion has been violated at time 29820.000000
|                 | |       | ((ref_high.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= ref_high.periodicDose.absorptionLumen.C, has value: -1.0255e-08"
LOG_ASSERT        | info    | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable]
|                 | |       | The following assertion has been violated at time 29820.000000
|                 | |       | ((ref_high.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= ref_high.periodicDose.absorptionLumen.M, has value: -1.0255e-08"
LOG_STATS         | info    | gbode (single-rate integration): radauIIA3
LOG_STATS         | info    | ### STATISTICS ###
|                 | |       | | timer
|                 | |       | | |            0s          reading init.xml
|                 | |       | | |            0s          reading info.xml
|                 | |       | | |   7.5953e-05s [  0.4%] pre-initialization
|                 | |       | | |  0.000110818s [  0.6%] initialization
|                 | |       | | |            0s [  0.0%] steps
|                 | |       | | |            0s [  0.0%] solver (excl. callbacks)
|                 | |       | | |    2.976e-06s [  0.0%] creating output-file
|                 | |       | | |  0.000510396s [  2.7%] event-handling
|                 | |       | | |            0s [  0.0%] overhead
|                 | |       | | |    0.0184464s [ 96.3%] simulation
|                 | |       | | |    0.0191465s [100.0%] total
|                 | |       | | events
|                 | |       | | |   110 state events
|                 | |       | | |     6 time events
|                 | |       | | solver: gbode
|                 | |       | | |  1592 steps taken
|                 | |       | | |  6612 calls of functionODE
|                 | |       | | |   120 evaluations of jacobian
|                 | |       | | |    64 error test failures
|                 | |       | | |     0 convergence test failures
|                 | |       | | | 0s time of jacobian evaluation
LOG_SUCCESS       | info    | The simulation finished successfully.