Environment - simulationEnvironment: startTime=0 stopTime=86400 tolerance=1e-12 numberOfIntervals=86 stepSize=1004.65 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.Pharmacogenomics.PK_2C_single -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 57670.200000 | | | | ((patient.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= patient.periodicDose.absorptionLumen.C, has value: -1.76285e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 57670.200000 | | | | ((patient.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= patient.periodicDose.absorptionLumen.M, has value: -1.76285e-08" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.0010719s reading init.xml | | | | | | 0.000109636s reading info.xml | | | | | | 9.3196e-05s [ 4.4%] pre-initialization | | | | | | 2.7812e-05s [ 1.3%] initialization | | | | | | 4.178e-06s [ 0.2%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 2.4424e-05s [ 1.1%] event-handling | | | | | | 8.481e-06s [ 0.4%] overhead | | | | | | 0.00196871s [ 92.6%] simulation | | | | | | 0.0021268s [100.0%] total | | | | | events | | | | | | 26 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 1005 steps taken | | | | | | 4014 calls of functionODE | | | | | | 30 evaluations of jacobian | | | | | | 41 error test failures | | | | | | 0 convergence test failures | | | | | | 1.2162e-05s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.