Environment - simulationEnvironment: startTime=0 stopTime=864000 tolerance=1e-09 numberOfIntervals=86400 stepSize=10 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.PK_Lithium.PK_1C_Lithium_CI -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_lower.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_lower.periodicDose.absorptionLumen.M, has value: -2.38095e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_lower.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_lower.periodicDose.variableDose.TotalCumulativeMass, has value: -2.36606e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_1C_Lithium_upper.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_1C_Lithium_upper.periodicDose.absorptionLumen.M, has value: -1.42857e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_1C_Lithium_upper.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_1C_Lithium_upper.periodicDose.variableDose.TotalCumulativeMass, has value: -1.41964e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_1C_Lithium.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_1C_Lithium.periodicDose.absorptionLumen.M, has value: -9.52381e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 659.918833 | | | | ((pK_1C_Lithium.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= pK_1C_Lithium.periodicDose.variableDose.TotalCumulativeMass, has value: -9.46425e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 173460.000000 | | | | ((pK_lower.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= pK_lower.periodicDose.absorptionLumen.C, has value: -1.31569e-07" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 173460.000000 | | | | ((pK_1C_Lithium_upper.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= pK_1C_Lithium_upper.periodicDose.absorptionLumen.C, has value: -7.89414e-07" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 173460.000000 | | | | ((pK_1C_Lithium.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= pK_1C_Lithium.periodicDose.absorptionLumen.C, has value: -5.26276e-07" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.00232173s reading init.xml | | | | | | 0.000230012s reading info.xml | | | | | | 0.0001221s [ 0.1%] pre-initialization | | | | | | 6.2938e-05s [ 0.1%] initialization | | | | | | 1.3756e-05s [ 0.0%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 0.00239628s [ 2.2%] event-handling | | | | | | 0.00419948s [ 3.8%] overhead | | | | | | 0.102646s [ 93.8%] simulation | | | | | | 0.10944s [100.0%] total | | | | | events | | | | | | 139 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 1206 steps taken | | | | | | 5295 calls of functionODE | | | | | | 150 evaluations of jacobian | | | | | | 134 error test failures | | | | | | 0 convergence test failures | | | | | | 7.7659e-05s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.