Environment - simulationEnvironment: startTime=0 stopTime=864000 tolerance=1e-09 numberOfIntervals=86400 stepSize=10 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.PK_Lithium.PK_1C_Lithium -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 646.055757 | | | | ((periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= periodicDose.absorptionLumen.M, has value: -1.42857e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 646.055757 | | | | ((periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= periodicDose.variableDose.TotalCumulativeMass, has value: -1.4326e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((central.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= central.C, has value: -2.79559e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((central.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= central.M, has value: -6.34599e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((periodicDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= periodicDose.TotalCumulativeMass, has value: -6.34601e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= periodicDose.absorptionLumen.C, has value: -4.2988e-07" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Pharmacokinetic/Models/PK_1C.mo:27:3-28:174:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((C_central >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= C_central, has value: -2.79559e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 660.181000 | | | | ((central.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= central.Cmin, has value: -2.91554e-09" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.000884442s reading init.xml | | | | | | 0.000100439s reading info.xml | | | | | | 0.000122601s [ 0.2%] pre-initialization | | | | | | 4.255e-05s [ 0.1%] initialization | | | | | | 1.2223e-05s [ 0.0%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 0.000652679s [ 1.2%] event-handling | | | | | | 0.00302609s [ 5.6%] overhead | | | | | | 0.050465s [ 92.9%] simulation | | | | | | 0.0543211s [100.0%] total | | | | | events | | | | | | 59 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 970 steps taken | | | | | | 4064 calls of functionODE | | | | | | 67 evaluations of jacobian | | | | | | 107 error test failures | | | | | | 0 convergence test failures | | | | | | 1.8198e-05s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.