Environment - simulationEnvironment: startTime=0 stopTime=86400 tolerance=1e-06 numberOfIntervals=500 stepSize=172.8 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.PK_Caffeine.PK_population_Caffeine -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((green_tee_drinker.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= green_tee_drinker.periodicDose.absorptionLumen.C, has value: -1.24803e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((green_tee_drinker.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= green_tee_drinker.periodicDose.absorptionLumen.M, has value: -1.24803e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((green_tee_drinker.periodicDose.absorptionLumen.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= green_tee_drinker.periodicDose.absorptionLumen.Cmin, has value: -1.24803e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((green_tee_drinker.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= green_tee_drinker.periodicDose.variableDose.TotalCumulativeMass, has value: -1.21669e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((black_tea_drinker.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= black_tea_drinker.periodicDose.absorptionLumen.C, has value: -1.89095e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((black_tea_drinker.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= black_tea_drinker.periodicDose.absorptionLumen.M, has value: -1.89095e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((black_tea_drinker.periodicDose.absorptionLumen.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= black_tea_drinker.periodicDose.absorptionLumen.Cmin, has value: -1.89095e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((black_tea_drinker.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= black_tea_drinker.periodicDose.variableDose.TotalCumulativeMass, has value: -1.84346e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((coffee_drinker.periodicDose.absorptionLumen.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= coffee_drinker.periodicDose.absorptionLumen.C, has value: -3.59281e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((coffee_drinker.periodicDose.absorptionLumen.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= coffee_drinker.periodicDose.absorptionLumen.M, has value: -3.59281e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((coffee_drinker.periodicDose.absorptionLumen.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= coffee_drinker.periodicDose.absorptionLumen.Cmin, has value: -3.59281e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 654.621946 | | | | ((coffee_drinker.periodicDose.variableDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= coffee_drinker.periodicDose.variableDose.TotalCumulativeMass, has value: -3.50258e-08" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((green_tee_drinker.central.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= green_tee_drinker.central.M, has value: -1.24541e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((green_tee_drinker.periodicDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= green_tee_drinker.periodicDose.TotalCumulativeMass, has value: -1.21799e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((black_tea_drinker.central.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= black_tea_drinker.central.M, has value: -1.88698e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((black_tea_drinker.periodicDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= black_tea_drinker.periodicDose.TotalCumulativeMass, has value: -1.84545e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((coffee_drinker.central.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= coffee_drinker.central.C, has value: -1.02436e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:18:3-18:49:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((coffee_drinker.central.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= coffee_drinker.central.M, has value: -3.58526e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialDrugSource.mo:6:9-6:96:writable] | | | | The following assertion has been violated at time 660.000000 | | | | ((coffee_drinker.periodicDose.TotalCumulativeMass >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= coffee_drinker.periodicDose.TotalCumulativeMass, has value: -3.50635e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 660.630311 | | | | ((green_tee_drinker.central.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= green_tee_drinker.central.C, has value: -1.19458e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 660.630311 | | | | ((green_tee_drinker.central.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= green_tee_drinker.central.Cmin, has value: -1.19458e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:9:3-9:108:writable] | | | | The following assertion has been violated at time 660.630311 | | | | ((black_tea_drinker.central.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= black_tea_drinker.central.C, has value: -1.80997e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 660.630311 | | | | ((black_tea_drinker.central.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= black_tea_drinker.central.Cmin, has value: -1.80997e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialCompartment.mo:21:3-21:56:writable] | | | | The following assertion has been violated at time 660.630311 | | | | ((coffee_drinker.central.Cmin >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= coffee_drinker.central.Cmin, has value: -3.43894e-09" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.00211818s reading init.xml | | | | | | 0.000222288s reading info.xml | | | | | | 0.000103354s [ 6.9%] pre-initialization | | | | | | 4.6688e-05s [ 3.1%] initialization | | | | | | 6.042e-06s [ 0.4%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 3.6561e-05s [ 2.4%] event-handling | | | | | | 2.7801e-05s [ 1.8%] overhead | | | | | | 0.00128287s [ 85.3%] simulation | | | | | | 0.00150332s [100.0%] total | | | | | events | | | | | | 13 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 99 steps taken | | | | | | 385 calls of functionODE | | | | | | 14 evaluations of jacobian | | | | | | 2 error test failures | | | | | | 0 convergence test failures | | | | | | 8.238e-06s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.