Environment - simulationEnvironment: startTime=0 stopTime=7200 tolerance=1e-06 numberOfIntervals=7200 stepSize=1 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.PBPK_SingleDoseVenousArteryTissue -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:8:3-8:92:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((tissue.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= tissue.C, has value: -3.93537e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:9:3-9:69:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((tissue.CB >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= tissue.CB, has value: -3.93537e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:13:3-13:85:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((tissue.freeBloodConc >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= tissue.freeBloodConc, has value: -3.93537e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:15:3-15:33:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((tissue.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= tissue.M, has value: -1.57415e-10" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Pharmacokinetic/ClearanceDrivenElimination.mo:5:3-5:115:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((kidneyElim.C >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= kidneyElim.C, has value: -3.93537e-09" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.00129905s reading init.xml | | | | | | 0.000110077s reading info.xml | | | | | | 0.000166693s [ 2.0%] pre-initialization | | | | | | 4.7179e-05s [ 0.6%] initialization | | | | | | 8.906e-06s [ 0.1%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 7.4258e-05s [ 0.9%] event-handling | | | | | | 0.000350347s [ 4.1%] overhead | | | | | | 0.00785356s [ 92.4%] simulation | | | | | | 0.00850094s [100.0%] total | | | | | events | | | | | | 5 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 59 steps taken | | | | | | 218 calls of functionODE | | | | | | 7 evaluations of jacobian | | | | | | 1 error test failures | | | | | | 0 convergence test failures | | | | | | 4.821e-06s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.