Environment - simulationEnvironment: startTime=0 stopTime=3600 tolerance=1e-06 numberOfIntervals=3600 stepSize=1 Regular simulation (gbode: the generic bi-rate ODE solver, with the radauIIA3 method): ./Pharmacolibrary_Pharmacolibrary.Examples.PBPK_OralDoseGUTWholeBody -abortSlowSimulation -alarm=240 -lv LOG_STATS -s gbode -gbm=radauIIA3 LOG_STDOUT | warning | Numerical Jacobians without coloring are currently not supported by GBODE. Colored numerical Jacobian will be used. LOG_SUCCESS | info | The initialization finished successfully without homotopy method. LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:9:3-9:69:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((venous.CB >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= venous.CB, has value: -5.71934e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:11:3-11:77:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((venous.freeTissueConc >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= venous.freeTissueConc, has value: -5.71934e-09" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Interfaces/PartialBloodTissueCompartment.mo:15:3-15:33:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((venous.M >= -1e-12)) --> "Variable violating min constraint: -1e-12 <= venous.M, has value: -2.28774e-11" LOG_ASSERT | info | [/home/hudson/saved_omc/libraries/.openmodelica/libraries/Pharmacolibrary 25.9.0/Pharmacokinetic/FlowGround.mo:4:3-4:109:writable] | | | | The following assertion has been violated at time 61.000000 | | | | ((flowGround.MassConcentration >= -1e-9)) --> "Variable violating min constraint: -1e-9 <= flowGround.MassConcentration, has value: -5.71934e-09" LOG_STATS | info | gbode (single-rate integration): radauIIA3 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.00293641s reading init.xml | | | | | | 0.000264147s reading info.xml | | | | | | 0.00013288s [ 1.5%] pre-initialization | | | | | | 5.4032e-05s [ 0.6%] initialization | | | | | | 5.751e-06s [ 0.1%] steps | | | | | | 0s [ 0.0%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 0.000151805s [ 1.8%] event-handling | | | | | | 0.000166443s [ 1.9%] overhead | | | | | | 0.00810007s [ 94.1%] simulation | | | | | | 0.00861099s [100.0%] total | | | | | events | | | | | | 78 state events | | | | | | 0 time events | | | | | solver: gbode | | | | | | 254 steps taken | | | | | | 1154 calls of functionODE | | | | | | 79 evaluations of jacobian | | | | | | 0 error test failures | | | | | | 0 convergence test failures | | | | | | 0.000616154s time of jacobian evaluation LOG_SUCCESS | info | The simulation finished successfully.