Environment - simulationEnvironment: startTime=0 stopTime=1.1 tolerance=1e-14 numberOfIntervals=2500 stepSize=0.00044 Regular simulation: ./Physiolibrary_Physiolibrary.Chemical.Examples.Hemoglobin.Develop.Hemoglobin_titration_shifts -abortSlowSimulation -alarm=480 -lv LOG_STATS LOG_SUCCESS | info | The initialization finished successfully without homotopy method. DASKR-- AT T (=R1) TOO MUCH ACCURACY REQUESTED In above message, R1 = 0.0000000000000E+00 DASKR-- FOR PRECISION OF MACHINE. RTOL AND ATOL DASKR-- WERE INCREASED BY A FACTOR R (=R1) In above message, R1 = 1.1102230246252E+00 stdout | warning | The error tolerances are too stringent stdout | warning | can't continue. time = 0.000000 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[1].products[1].conc >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[1].products[1].conc, has value: -5.42101e-17 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[2].products[1].conc >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[2].products[1].conc, has value: -5.42101e-17 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[3].products[1].conc >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.carboxylation[3].products[1].conc, has value: -5.42101e-17 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[1].state >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[1].state, has value: -5.42101e-20 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[2].state >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[2].state, has value: -5.42101e-20 assert | warning | The following assertion has been violated at time 0.000000 | | | | hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[3].state >= 0.0 assert | warning | Variable violating min constraint: 0.0 <= hemoglobin_titration5.deoxyhemoglobin.T.NHCOO[3].state, has value: -5.42101e-20 stdout | info | model terminate | Integrator failed. | Simulation terminated at time 0 LOG_STATS | info | ### STATISTICS ### | | | | | timer | | | | | | 0.306725s reading init.xml | | | | | | 0.0412982s reading info.xml | | | | | | 0.00143034s [ 11.7%] pre-initialization | | | | | | 0.00756861s [ 62.2%] initialization | | | | | | 0.00300326s [ 24.7%] steps | | | | | | 4.6507e-05s [ 0.4%] solver (excl. callbacks) | | | | | | 0s [ 0.0%] creating output-file | | | | | | 0.00102771s [ 8.4%] event-handling | | | | | | 9.588e-06s [ 0.1%] overhead | | | | | | -0.000912421s [ -7.5%] simulation | | | | | | 0.0121736s [100.0%] total | | | | | events | | | | | | 0 state events | | | | | | 0 time events | | | | | solver: dassl | | | | | | 0 steps taken | | | | | | 0 calls of functionODE | | | | | | 0 evaluations of jacobian | | | | | | 0 error test failures | | | | | | 0 convergence test failures | | | | | | 0s time of jacobian evaluation